Theoretical Aspects of Creating the Business Models for Supply Chain Process of Industrial Enterprises

Abstract- Creating the business models for supply chain process is the subject of modern scientific research in the field of strategic planning and management of the enterprise. Some theoretical and practical aspects have not yet received a comprehensive scientific substantiation. General problem of enterprise management is traditionally analyzed in the researches, and business modeling is not fully investigated. The current state of the economy and peculiarities of its development, as well as the transformational nature of the Russian economy, show that the most important theoretical and practical aspects, which require scientific attention and development, analysis and systematization, are the theoretical provisions of business modeling concept for supply chain process; clarification of the term "business model" for supply chain process of an industrial enterprise; definition of the main elements and substantiation of the technology of business model formation; systematization and generalization of modern methods of strategic analysis; formation of an integrated system for assessment the effectiveness of the enterprises business model for supply chain process. The issues of strategic development of the enterprise always arouse a great interest among researchers. Today, a significant number of business models have been created for the development of enterprises of various industry structures. The purpose of the article is to systematize the information about the creation of business models for supply chain process of industrial enterprises, to consider the features of the models use at the present stage. Scientific and theoretical basis of the research was the methods of analysis and synthesis, scientific abstraction, the use of quantitative and qualitative assessment methods, with the help of which the categories of the concept business model for the supply chain process were defined. Endogenous and exogenous factors, influencing the functioning of enterprises business models were identified. The article deals with the conceptual issues of the business model for the supply chain process formation, in particular, the essence and peculiarities of modern business models, as well as management approaches to the processes of development of enterprises business model for supply chain process. Keywords: business model, strategic development, industrial enterprise, supply chain process, creation

Identification of materials in X-ray inspections of objects by the dual-energy method

The state-of-the-art, application experience, and trends in further perfection of the dualenergy method as used in digital-radiography and X-ray computed-tomography systems intended for nondestructive testing and screening of objects are reviewed

The Basis and Possibility of Students’ Participation in Supply Chain Entrepreneurship (Case Study: Primorsky Territory)

Abstract- The current stage of development of the Russian economy, indicated by the increase in food sanctions, unemployment and the decline in growth rates, requires the introduction of import substitution mechanisms and a significant strengthening of the national entrepreneurship environment. Youth entrepreneurship plays a special role in the development of Russian small and medium-sized businesses. At the strategic and legislative levels, various programs are developed to support small business in this area. However, there are still some barriers, limiting the spread of small and medium-sized business among young people. In this regard, the problem of agitation of entrepreneurship among young people is important. This article presents the results of selective study, in which the supply chain entrepreneurial climate among the students of higher educational institutions of Primorsky Territory, using the method of sociological survey. The readiness of young people to start their own business was analysed, and unfavourable factors, complicating the development of this process, were identified. The authors defined key competences, determining the entrepreneur. The conclusion was made about the need for development, and necessary measures of state support for youth supply chain entrepreneurship. Keywords- supply chain entrepreneurship, Primorsky Territory, business incubator, small business, young people, Russia

Snake venom phospholipase A2s exhibit strong virucidal activity against SARS-CoV-2 and inhibit the viral spike glycoprotein interaction with ACE2.

The COVID-19 pandemic caused by SARS-CoV-2 requires new treatments both to alleviate the symptoms and to prevent the spread of this disease. Previous studies demonstrated good antiviral and virucidal activity of phospholipase A2s (PLA2s) from snake venoms against viruses from different families but there was no data for coronaviruses. Here we show that PLA2s from snake venoms protect Vero E6 cells against SARS-CoV-2 cytopathic effects. PLA2s showed low cytotoxicity to Vero E6 cells with some activity at micromolar concentrations, but strong antiviral activity at nanomolar concentrations. Dimeric PLA2 from the viper Vipera nikolskii and its subunits manifested especially potent virucidal effects, which were related to their phospholipolytic activity, and inhibited cell-cell fusion mediated by the SARS-CoV-2 spike glycoprotein. Moreover, PLA2s interfered with binding both of an antibody against ACE2 and of the receptor-binding domain of the glycoprotein S to 293T/ACE2 cells. This is the first demonstration of a detrimental effect of PLA2s on β-coronaviruses. Thus, snake PLA2s are promising for the development of antiviral drugs that target the viral envelope, and could also prove to be useful tools to study the interaction of viruses with host cells

Correction to: Two years later: Is the SARS-CoV-2 pandemic still having an impact on emergency surgery? An international cross-sectional survey among WSES members

Background: The SARS-CoV-2 pandemic is still ongoing and a major challenge for health care services worldwide. In the first WSES COVID-19 emergency surgery survey, a strong negative impact on emergency surgery (ES) had been described already early in the pandemic situation. However, the knowledge is limited about current effects of the pandemic on patient flow through emergency rooms, daily routine and decision making in ES as well as their changes over time during the last two pandemic years. This second WSES COVID-19 emergency surgery survey investigates the impact of the SARS-CoV-2 pandemic on ES during the course of the pandemic. Methods: A web survey had been distributed to medical specialists in ES during a four-week period from January 2022, investigating the impact of the pandemic on patients and septic diseases both requiring ES, structural problems due to the pandemic and time-to-intervention in ES routine. Results: 367 collaborators from 59 countries responded to the survey. The majority indicated that the pandemic still significantly impacts on treatment and outcome of surgical emergency patients (83.1% and 78.5%, respectively). As reasons, the collaborators reported decreased case load in ES (44.7%), but patients presenting with more prolonged and severe diseases, especially concerning perforated appendicitis (62.1%) and diverticulitis (57.5%). Otherwise, approximately 50% of the participants still observe a delay in time-to-intervention in ES compared with the situation before the pandemic. Relevant causes leading to enlarged time-to-intervention in ES during the pandemic are persistent problems with in-hospital logistics, lacks in medical staff as well as operating room and intensive care capacities during the pandemic. This leads not only to the need for triage or transferring of ES patients to other hospitals, reported by 64.0% and 48.8% of the collaborators, respectively, but also to paradigm shifts in treatment modalities to non-operative approaches reported by 67.3% of the participants, especially in uncomplicated appendicitis, cholecystitis and multiple-recurrent diverticulitis. Conclusions: The SARS-CoV-2 pandemic still significantly impacts on care and outcome of patients in ES. Well-known problems with in-hospital logistics are not sufficiently resolved by now; however, medical staff shortages and reduced capacities have been dramatically aggravated over last two pandemic years

Контент-анализ в рамках сетевого подхода к исследованию основ российской государственности в доромановский период

This article presents to the reader’s a part of the results of a comprehensive study of the foundations of Russian statehood using a network approach, including the use of content analysis to overcome the limitations of the concept of political networks as a meso-level concept. The purpose of the article is to review the method and methodology of content analysis in the context of applying the network approach to the study of the formation of Russian statehood in the pre-Roman era. In addition to justifying the use of content analysis, modern software, its capabilities and methods of work are considered. Based on the data provided, conclusions are drawn about the possibility of effective use of content analysis as an additional tool for collecting and forming a database for further building network models. In our opinion, the material of the article can also be useful to a wide range of researchers who plan to use content analysis in studies of the state and society.Данная статья представляет вниманию читателя часть результатов комплексного исследования основ российской государственности с применением сетевого подхода, касающуюся использования контент-анализа для преодоления ограничений концепции политических сетей как концепции мезоуровня. Целью статьи является обзор метода и методики контент-анализа в контексте применения сетевого подхода при исследовании становлений государственности России в доромановский период. Помимо обоснования использования контент-анализа рассматриваются современное программное обеспечение, его возможности и методики работы. На основании предоставленных данных делаются выводы о возможности эффективного использования контент-анализа в качестве дополнительного инструмента сбора и формирования базы данных для дальнейшего построения сетевых моделей. На наш взгляд, материал статьи может быть также полезен широкому кругу исследователей, планирующих использовать контент-анализ в исследованиях государства и общества

Возможности использования сетевого подхода в исследованиях государственности России в доромановский период

This article aims to consider the possibility of using the network approach in domestic research on the foundations of the formation of statehood in the pre-Roman period of Russian political history. The paper pays special attention to the situation, existing methods and principles of the network approach in the context of the problem under consideration, as well as their applicability, taking into account the time frame and the amount of data available for analysis.Данная статья ставит своей целью рассмотрение возможности использования сетевого подхода в отечественных исследованиях основ становления государственности в доромановский период российской политической истории. В работе особое внимание уделяется положению, существующим методам и принципам сетевого подхода в контексте рассматриваемой проблематики, а также их применимости, с учетом временных рамок и количества доступных для анализа данных

About the structure of geographical time

Исследуется категория времени как умопостигаемое понятие (ноумен) в герметической соподчиненности. Выделены атрибуты категории: ли- нейное, цикличное, скалярное время. Линейное время (стрела времени) отображает противопоставление порядка хаосу, поэтому время появляется при упорядоченно- сти, в казуальной событийной последовательности. Для материальных объектов, имеющих начало и конец, «стрела времени» превращается в «жизненный цикл», состоящий из множества частных циклов. В мире существует бесконечное количе- ство пересекающихся последовательностей, собственно и образующих событийный ряд. Пересечения (узлы) формируют «ткань времени», которая многомерна, по- скольку в каждом из пересечений объект предстает в разных качествах. «Ткань времени» закреплена в виртуальном внутривременном пространстве, координаты которого заданы «скалярным временем», простыми отметками в стандартной скалярной временной шкале. Внутривременное пространство является замените- лем (суррогатом) реального географического пространства. В нем содержатся компоненты идеального, астрального, мотивационного планов бытия, а также средства синхронизации разнородных процессов, поэтому оно является мощным средством управления. Рассмотрены релятивистские особенности шкал измерения времени, скорость времени, ритмы и гармоники . The category of time as intelligible notion (noumenon) in impermeable hierarchy is under investigation. The following category attributes are distinguished: linear, cyclic and scalar time. Linear time (arrow of time) represents contraposition of order to chaos; that is why time appears when orderliness happens, in causal eventful progression. For tangible objects, having the beginning and the end, «the arrow of time» turns to be a «life cycle», consisting of a number of specific cycles. There exists in the world an infinity of crossing sequences, which form an event line. Intersections (junctions) make «fabric of time», which is multidimensional, as in every junction the object appears in various attributes. «Fabric of time» is fixed in virtual inter-temporal space, the coordinates of which are set by «scalar time», ordinary grades in the standard scalar time scale. Inter-temporal space is a substitute (surrogate) of real geographical space. It contains the components of ideal, astral, motivational scheme of things, as well as tools of inconsistent process synchronization and thus being a powerful means of control. Relativistic characteristics of time measuring scales, time velocity, rhythms and harmonics of geographical systems have been reviewed

Identification of materials in X-ray inspections of objects by the dual-energy method

The state-of-the-art, application experience, and trends in further perfection of the dualenergy method as used in digital-radiography and X-ray computed-tomography systems intended for nondestructive testing and screening of objects are reviewed